The Research: Dim-Light escalates breast cancer’s spread to bones

A latest research has found out that, “Exposure to ‘dim-light’ at night, which is common in today’s lifestyle, may contribute to spreading of ‘breast cancer’ to bones”, recent researchers have shown in an animal study. The research identified the significance of an intact nocturnal circadian melatonin anti-cancer signal in suppressing bone-metastatic breast tumour growth.

Meanwhile, Muralidharan Anbalagan, Assistant Professor, at Tulane University in New Orleans were assumed that, When breast cancer spreads it often affects bones, cause severe pain and make them fragile. “To date no one has reported that exposure to dim light at night induces circadian disruption, which increases spread of bone metastatic breast cancer,”.

Breast cancer is a disease in which cells in the breast grow out of control. There are different kinds of breast cancer. The kind of breast cancer depends on which cells in the breast turn into cancer.

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This is important, as many patients with breast cancer are likely exposed to light at night as a result of lack of sleep, stress, excess light in the bedroom from mobile devices and other sources, or night shift work. More than 150,000 U.S. women had breast cancer in 2017 that metastasized, or spread outside the breast, according to an estimate from the National Cancer Institute. When breast cancer spreads, it often goes to the bones, where it can cause severe pain and fragile bones. The Research Syudy asserted.

The findings were presented at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans.

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In the preliminary research funded by the Louisiana Clinical and Translational Science Center (LACATS) in collaboration with Louisiana Cancer Research Consortium (LCRC) & Tulane Center for Circadian Biology, the researchers team were created a mouse model of bone metastatic breast cancer, which have a low propensity to grow in bones into the tibia (shinbone). And They injected estrogen receptor-positive human breast cancer cells that have a low propensity to grow in bones into the tibia, or shinbone, of female mice.

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Moreover, All mice were kept in the light for 12 hours each day. One group of three mice was in the dark the other 12 hours, which helped them produce high levels of endogenous melatonin. Another group spent 12 hours in light followed by 12 hours in dim light at night, which suppresses their nocturnal melatonin production. The dim light was 0.2 lux, which is less than a night-light or a display light from a cell phone. The Research.

Consequently, X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle. Results of the study has been presented on March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. The ultimate goal of their research, is to find a way to inhibit or suppress the progression of breast cancer metastases to bone.

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Despite the research, According to the The World Health Organization (WHO) 17 people dies every minute from Cancer, the estimated number of deaths due to the same in 2018 was 9.5 million, following the recent reports, which amounts to a whopping 26,000 deaths a day and the number is expected to increase as environmental stresses increase, air quality worsens, lifestyles and eating habits too! In 2015, 8.8 million people died from cancer, mostly in low- and middle-income countries. Globally, common challenges to cancer control are delays in cancer diagnosis and inaccessible treatment.

Salvestrol as the “Trojan Horse” for Cancer Cells

Salvestrol is unique in that it came into being as a phytochemical categorization specifically because of its relationship to cancer cells. It was first discovered by researchers Gerry Potter, Professor of Medical Chemistry at De Montfort University in the UK, and Dan Burke, Professor Emeritus at North Carolina State University.  They were in the middle of researching how synthetic drugs could potentially target cancer cells without harming healthy cells when they discovered an all-natural substance that was able to do this without side effects. Once they discovered Salvestrol in plants, they decided to devote all their time to studying how it works (for the benefit of us all!).

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Based on their initial research in the early 2000’s and many other studies since then, we now know that the phytochemical defined as “salvestrol” has a unique relationship to a particular enzyme that is only found within cancer cells. This enzyme is known as “CYP1B1.” Thus, The recently-discovered class of phytonutrient called salvestrols is definitely one of the heavy-hitters when it comes to protecting the body against breast cancer and other kinds of cancer. Even in countries with strong health systems and services, many cancer cases are diagnosed at a late-stage, when they are harder to treat successfully.

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The year, also remarked the launch of the 3-year ‘I Am and I Will’ campaign followed by ‘World Cancer Day 2019’. Whoever you are, you have the power to reduce the impact of cancer for yourself, the people you love and for the world. It’s time to make a personal commitment, I am and I will. It is an empowering call-to-action urging for personal commitment and represents the power of individual action taken now to impact the future.

Author: Trilok Singh, MA in Political Science, Kirori Mal College, University of Delhi. Professional-Scholar and CEO at Youth Darpan, India’s Journal and IASmind. 

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